Chloride

Chloride (Cl), a macromineral and electrolyte, is the principal extracellular and intracellular anion counter to sodium and potassium cations (anions are negatively charged particles, while cations are positively charged particles). Total body chloride in adult males is estimated at 1.2 g / kg of body weight, with some 70 % located in the extracellular fluid (ECF) and the remainder in the intracellular compartment, connective tissue and bone. Chloride is almost completely absorbed in the intestine and excreted in the urine and sweat.

Functions

Chloride, as a mineral and electrolyte, has many important functions in the body including:

  • helping to maintain water balance and osmotic pressure
  • maintaining the body’s acid – base balance
  • assisting in the regulation of the renin – angiostensin – aldosterone system (more commonly known as the blood pressure system)

Reference Intake (RI)

 

    AGE

   CHILDREN

    MALES

FEMALES

MALES

FEMALES

PREGNANCY

YEARS

1-3

4-6

7-10

11-14

15-17

11-14

15-17

18-64

65+

18-64

65+

 

Chloride (mg / d)

800

1100

1800

2500

2500

2500

2500

2500

2500

2500

2500

 (No increment)

 

    MONTHS

0-3

4-6

7-9

10-12

LACTATION

Chloride (mg / d)

320

400

500

500

 (No increment)

Food Sources

Most dietary chloride comes from sodium chloride, Na+Cl- (table salt), which is about 60 % chloride by weight. It is thought that the chloride found in drinking water only contributes a small part of our daily intake.

Deficiency / Toxicity

As dietary intake and metabolism of chloride and sodium typically proceed in parallel, cases of deficiency occur at a similar frequency, may be mediated by similar factors, and result in comparable symptoms, to that of hyponatraemia.  

Since chloride is excreted through urine and sweat, toxicity is extremely rare.

As mentioned before in relation to sodium, high dietary salt (of which chloride is a component) intakes disrupt the electrolyte balance of the body and may increase blood pressure and risk of stroke.  

Factors influencing the uptake of chloride

High intake of caffeine and alcohol may hinder the uptake of chloride.